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pentobarbital will decrease the extent or effect of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Pitolisant publicity is reduced by 50% if coadministered with robust CYP3A4 inducers.buprenorphine subdermal implant and pentobarbital each raise sedation. Stay away from or Use Alternate Drug. Res